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The U.S. Food and Drug Administration reviewed Contrave on December 7, and approved the drug 13-7, stating the advantages of the drug outweighs the potential risk of a possible rise in blood pressure. Using two separate drugs to lose weight can be very effective you can find combinations as you're watching FDA now awaiting approval. When dealing with weight reduction and the individuals who go through it you ought to err to the side of caution and allow the FDA do its job and demand some investigation be done so your public understands the side effects and dangers of the medications before we bring them. Keep in mind that drug companies have been in business to generate income and that they would say anything to keep people on his or her medications. Researchers discovered that participants taking this drug for a year, dropped excess weight within one month and have kept the load off during the entire 56 weeks with the study. Contrave is a combination with the drugs naltrexone and bupropion, which usually reflect a new trend of weight-loss drugs which might be made up of multiple active ingredient, that might make them more effective and safer. Combo-pilling will be the newest fad or also the newest into the future under scrutiny and for that reason it is just more publicly known in recent months, comb-pilling for weight loss has been around since the eighties. The biggest reason that by using a combination of pills is starting to become popular may be the fact that since right now there aren't any long term prescription weight loss supplements that have been authorized by the FDA apart from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications and some of the combinations have been rejected or have yet to be licensed by the FDA. Seizures certainly are a side effect with Contrave and must not be taken in people who have seizure disorders. The drug also can raise blood pressure level and heartbeat, and mustn't be used in people who have a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise blood pressure levels and heartbeat and must not used in patients with uncontrolled high hypertension, as well as by you aren't heart-related and cerebrovascular (circulation dysfunction impacting mental performance) disease. Patients which has a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes with a boxed warning to alert medical professionals and patients to the increased probability of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking. From a psychiatric viewpoint, evidence implies that the ordinary neural mechanism for goal-directed behavior continues to be hijacked through the addiction, and malfunctions in such a way that its ordinary functions are exaggerated and fixated on its object. An object creates a stimulus as well as the person engages in a "goal-directed behavioral response" that generates a "natural high"(Bostwick & Bucci, 2008).